Overveiw: Cisplatin (CIS) is a perfect antineoplastic medicine resulting in severe testicular
toxicity. Melatonin is a potent antioxidant that can prevent gonadal toxicity. exosomes have been
demonstrated to have a vital effect in tissue regeneration.
Aim: to evaluate the potential protective effects of melatonin and exosomes developed from
bone marrow mesenchymal stem cells (BMSC-EX) in testicular toxicity caused by cisplatin.
Materials and Methods: fifty rats were divided in a random way into five equal groups.
Group I (control group). Group II were given a single dose (8 mg/kg) of cisplatin
intraperitoneally I.P. Group III (melatonin group): intra peritoneal administration of melatonin
(4 ɱg/kg) started 5 days before cisplatin injection for 15 days. Group IV (exosomes group): a
single intra venous dose of 100 μց BMSC-EX one day before cisplatin dose. Group V
(melatonin and exosomes). Specimens of the testicles were collected and processed for
immunohistochemical and histological analysis. |
