You are in:Home/Publications/Correlations between Serum and Synovial fluid IL-17... concentrations with disease activity and severity of Rheumatoid Arthritis .

Ass. Lect. Samah Mohamed Abdel Khalek Hasanin :: Publications:

Title:
Correlations between Serum and Synovial fluid IL-17... concentrations with disease activity and severity of Rheumatoid Arthritis .
Authors: Author links open overlay panelMedhat A.FaragaFouad E.El DebakyaShaymaa M.Abd El-RahmanaSamah M.Abd el-khalekaRasha M.Fawzy
Year: 2020
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Samah Mohamed Abdel Khalek Hasanin_Serum-and-synovial-fluid-interleukin-17-concentrations-in-rhe_2020_The-Egypt.pdf
Supplementary materials Not Available
Abstract:

Aim of the work To investigate serum and synovial fluid levels of IL-17 in rheumatoid arthritis (RA) patients, and its correlation with disease activity and severity. Patients and methods 20 RA patients together with 20 primary knee osteoarthritis (KOA) patients and 15 healthy individuals matched for age and sex as control groups were enrolled in this study. Both RA and KOA patients presented with knee effusion. Paired samples of serum and synovial fluid (SF) were collected from RA, OA patients and serum samples from the healthy individuals. RA disease activity was assessed using DAS-28 score and power Doppler ultrasound (PDUS) according to the European League against Rheumatism (EULAR). Radiographic damage was evaluated according to Larsen score. Results Serum levels of IL-17 were significantly elevated in RA patients compared to controls (p < 0.001). Also, SF of IL-17 was significantly higher in RA patients compared to OA patients (p < 0.001). In addition, synovial level of IL-17 was significantly higher in RA patient compared to their serum level (p < 0.001). Regarding disease activity grading among RA patients, significant differences (p < 0.05) in mean serum and synovial IL-17 levels were reported being higher in severe active disease. Positive correlations of serum and SF IL 17 levels with PDUS findings and Larsen score were reported. Conclusion Serum and synovial IL-17 levels were significantly elevated in RA patients which clarifies its possible role in RA pathogenesis and correlates positively with disease activity parameters, PDUS findings and Larsen score. Thus targeting IL-17 may provide a promising role in suppressing RA.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus