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Prof. Amal Abou Idris Aly Youssef :: Publications:
Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA
|Authors:||Inas A Ahmed, Carsten M Pusch, Thanaa Hamed, Hamed Rashad, Amal Idris, Amal Abou El-Fadle, Nikolaus Blin|
|Journal:||Cancer genetics and cytogenetics|
|Full paper||Not Available|
|Supplementary materials||Not Available|
Novel strategies for early detection of breast cancer, the most common and second most lethal cancer in women, are urgently needed. Silencing tumor suppressor genes via DNA methylation has established hypermethylation as one of the most frequent molecular alterations that may initiate and drive many types of human neoplasia including breast cancer. Detecting such epigenetic changes in DNA derived not only from tumor tissue, but also from bodily fluids, may be a promising target for the molecular analysis of cancer.