| Title: | Significance of Serum Lipid Peroxides, Total and Lipid-Bound Sialic Acid as Markers for Liver Diseases. Departments of Biochemistry, Hepatology, Gastroentrology and Infectious Diseases and Internal Medicine Benha Faculty of Medicine Zagazig University Bull. Egypt. Soc. Physiol. Sci., 20 (1) |
| Authors: | Thanaa Hamed, Mahasen Abdel Sattar, Fatma Abd El-Salam, Sherif Abou El-Dahab, Amal Idris |
| Year: | 2000 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | Local |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
The purpose of this study is to evaluate the role of insulin-like growth factor binding protein-3 (IGFBP-3) in inflammatory and degenerative joint diseases by estimating its level in the serum and synovial fluid of patients with Rheumatoid arthritis (RA) and Osteoarthritis (OA) and correlating these levels to the clinical features of these disorders. Twenty RA patients, twenty-eight OA patients and fourteen healthy controls were included in this study All patients and controls were subjected to the following; full history, clinical examination, and laboratory investigation including Hb, ESR. estimation of the level of IGFBP-3 in both serum and synovial fluid by radioimmunoassay procedure. Plain x-ray for both knees & hands were also included. Patients with RA were divided according to their radiological findings into erosive and non erosive subgroups, and according to the mean disease activity grades (MDAG) into two groups, one including patients with MDAG1 & 2 and another including patients with MDAG3 & 4. OA patients were divided according to radiological findings into two subgroups, one including patients with grade I & II and another including grade III & IV patients. And according to score of functional severity, we subgrouped OA patients into two subgroups; one including patients with score < 7 and another including patients with score > 8 The present study showed no significant difference between the serum level of the IGFBP-3 of both RA and OA patients when compared to the controls. A significant increase (P < 0.05) was found in the synovial IGFBP-3 of RA patients when compared to the controls. No significant difference was found between synovial IGFBP-3 of OA patients when compared to the contfols. No Bull. Egypt. Soc. Physiol. Sci., 19(1) 1999 27 |
