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Prof. Abeer Abdelhameed Almahlawy :: Publications:

Title:
Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study.
Authors: Nahla El-Eraky El-Azab, Aisha E. Mansy, Abeer M. El-Mahalaway, Dina Sabry.
Year: 2018
Keywords: Bone marrow mesenchymal stem cells (BMSCs), gastric ulcer, pomegranate, tumor necrosis factor-α, vascular endothelial growth factor (VEGF).
Journal: The Egyptian journal of histology
Volume: 41
Issue: 2
Pages: 150-166
Publisher: Lippincott Williams and Wilkins
Local/International: Local
Paper Link:
Full paper Not Available
Supplementary materials Not Available
Abstract:

Introduction: Gastric ulcers are the most prevalent gastrointestinal disorders. Pomegranate fruits have many beneficial therapeutic effects. Bone marrow mesenchymal stem cells (BMSCs) are a novel approach with promising therapeutic potential for curing human diseases. Aim of the work: To evaluate the effect of pomegranate and BMSCs on experimentally induced gastric ulcer in adult male rats. Materials and Methods: Sixty adult male rats were divided into four groups. Group I kept as the control group. Group II (Gastric ulcer), rats received 100% ethanol orally by gastric tube. Group (III) subdivided into 3 subgroups. Subgroup IIIa included rats with gastric ulcer that treated with pomegranate only. Subgroup IIIb, rats with gastric ulcer treated with BMSCs alone. Subgroup IIIc; gastric ulcer rats treated with a combination of pomegranate and BMSCs. Group IV included the untreated gastric ulcer rats. Fundus of stomach specimens were prepared and examined using histological and immunohistochemical techniques. Results: Groups II and IV showed various changes as deep erosion, marked damage of most of the cells. The presence of the inflammatory cells in gastric mucosa were supported by a significant increase of tumor necrosis factor α (TNF-α) expression and collagen fibers depositions (P

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