Renin angiotensin system (RAS) is important for fluid and blood pressure regulation. Recent studies suggest that an overactive RAS is involved in the metabolic syndrome. The aim of this study was to examine the possible therapeutic effect of aliskiren (a renin inhibitor), lisinopril (ACEI) and irbesartan (ARB) in experimentally induced metabolic syndrome in rats and to compare between their effects. Thirty male albino rat were classified into five groups (n = 6 for each group): normal control group, metabolic syndrome- non treated group, metabolic syndrome was induced by ingestion of high fructose diet (60% fructose) for 8 weeks, metabolic syndrome induced group treated by aliskiren (100mg/kg/day) for 4weeks after induction of metabolic syndrome, metabolic syndrome induced group treated by lisinopril (10mg/kg/day) for 4weeks after induction of metabolic syndrome , metabolic syndrome induced group treated by irbesartan (30mg/kg/day) for 4weeks after induction of metabolic syndrome. The obtained results in the current work revealed that treatment of metabolic syndrome- induced rats by both aliskiren, lisinpril and irbesartan resulted in significant reduction of arterial blood pressure with more significant reduction in aliskiren treated group. Also the three drugs show improvement in hyperinsulinemia parameters with more significant improvement after aliskiren treatment. |
