Abstract
BACKGROUND: Obesity is associated with a number of chronic diseases, such as cardiovascular disease, diabetes, and hypertension. As a direct link between obesity and kidney disease is increasingly appreciated, obesity is becoming an issue with which all nephrologists have to familiarize themselves Smoking, a well known risk factor for many diseases, was recently proven to play an important role in renal diseases. Ginger is one of the most commonly used spices around the world. Ginger has been used to help treating arthritis, colic, diarrhea, and heart problems. Experimental evidence exists for potential benefit of ginger on kidney function. The investigators demonstrated that dietary supplementation with ginger offered significant renal protection by activating antioxidant pathways.
OBJECTIVE: To evaluate the effect of ginger on renal function of rats fed high sucrose diet and exposed to passive smoking.
MATERIALS AND METHODS: Forty male Albino rats were divide into 5 groups 8 rat/ cage either not treated (control), or fed high sucrose diet, or fed high sucrose diet with dietary ginger supplementation (500 mg/kg /d), fed high sucrose diet and exposed to passive smoking or fed high sucrose diet and exposed to passive smoking supplemented with ginger powder. After five weeks of treatment, final body weight was determined. Blood samples were collected, lipid parameters, blood glucose, serum urea and creatinine were determined. Kidney tissue isolated from rats for histopathological examination.
RESULTS: Treatment with ginger had significant effect in reducing body weight. Ginger had the ability to reduce glucose level, lipid profile; (triglyceride-cholesterol), serum level of urea and creatinine in both obese rats and those exposed to passive smoking. In addition; the histological study of the renal tissue showing improvement after ginger administration in both obese and passive smoking rats.
CONCLUSIONS: Ginger has a great ability to reduce body weight; blood glucose and lipid profile and has a protective effect against renal damage produced in obese rats and those exposed to passive smoking.
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