The purpose of this study is to evaluate, bone turnover in pre- and postmenopausal women with and without hip fractures by assessing bone formation and resorption markers and to elucidate their relation with the nutritional status. Fifty four osteoporotic postmenopausal women were divided into two groups: group 1 included 42 postmenopausal women without fractures and group 2 included 12 postmenopausal women with hip fractures. A third group consists of 16 premenopausal women was taken as control group. The serum level of calcium, osteocalcin (DC), bone alkaline phosphatase (.B-ALP) and urinary deoxypyridinoline (U-Dpd) were estimated for all groups. Serum OC and B-ALP of postmenopausal women with and without fractures were higher than that of premenopausal women. The values reported for OC of postmenopausal women with and without fractures were increased by 102% and 122% respectively over the pre menopausal women. The percent increase of B-ALP was 44.6% and 25.4%. The bone resorption marker, U-Dpd Wr. as significantly higher in case of postmenopausal women with and without fractures when compared with controls. In postmenopausal women without fractures, U-Dpd was increased by. 190% over the premenopausal women and reached 296.7% in patients with fractures. No significant difference was noted in serum calcium among the three groups. The intake of vitamin D in postmenopausal women with and without fractures were significantly lower than that of premenopausal women. There was no significant difference in the calcium intake among the three groups. |
