Objectives: To evaluate therapeutic yield of lifestyle intervention program on body mass index (BMI), insulin resistance (IR) and estimated laboratory markers in obese and diabetic children.
Patients & Methods: Thirty-five obese non-diabetic, 35 type-II diabetic and 20 control children and adolescents were studied. Study children underwent 12-weeks intervention consisted of dieting regimen, aerobic exercise with curcumin as herbal therapy. Serum insulin, progranulin (PGRN), tumor necrosis factor-α (TNF-α), adiponectin and YKL-40 levels were ELISA estimated. Insulin resistance was measured by homeostasis model assessment (HOMA-IR). BMI and HOMA-IR score and laboratory parameters were determined at start and end of the intervention.
Results: At end of intervention, BMI and HOMA-IR variables and score were significantly decreased compared to baseline measures. Baseline serum levels of PGRN, YKL-40 and TNF-α were significantly higher, but adiponectin levels were significantly lower in patients than controls and in diabetics than obese children. At end of intervention, serum PGRN and YKL-40 levels were significantly decreased than baseline levels with significantly higher levels in diabetics than obese. Despite of decreased serum TNF-α levels compared to baseline levels, it was still significantly higher in patients than controls and in diabetics than obese children. Serum adiponectin levels increased but were significantly lower in diabetics and non-significantly lower in obese compared to control levels with significantly higher levels in obese compared to diabetics.
Conclusion: This intervention program allowed reduction of BW and IR and could ameliorate disturbance of adipokines serum levels in obese and diabetic children. |
