Aflatoxin B1 (AFB1) is a common environmental pollutant that poses a major hazard to both humans and animals.
Acacia senegal (Gum) is well-known for having antioxidant and anti-inflammatory bioactive compounds.
Our study aimed to scout the nephroprotective effects of Acacia gum (Gum) against AFB1-induced renal damage.
Four groups of rats were designed: Control, Gum (7.5 mg/kg), AFB1 (200 μg/kg b.w) and AFB1-Gum, rats were
co-treated with both Gum and AFB1. Gas chromatography-mass spectrometry (GC/MS) analysis was done to
determine the phytochemical constituents in Gum. AFB1 triggered profound alterations in kidney function parameters
(urea, creatinine, uric acid, and alkaline phosphatase) and renal histological architecture. Additionally,
AFB1 exposure evoked up-regulation of mRNA expression levels of inflammatory cytokines, including
interleukin-6 (IL-6), tumor necrosis factor α (TNFα), inducible nitric oxide synthase (iNOS), and nuclear factor kB
p65 (NF-κB/P65) in renal tissue. The oxidative distress and apoptotic cascade are also instigated by AFB1
intoxication as depicted in down-regulated protein expression of the nuclear factor erythroid 2–related factor 2
(Nrf2) and superoxide dismutase type 1 (SOD1) along with upregulation of cytochrome c (Cyto c), and cleaved
Caspase3 (Casp3–17 and 19) in renal tissue. In conclusion, current study obviously confirms the alleviating |
