Melamine is considered as one of urea derivatives. Recently it is added to feed stuffs for industrial purposes (falsely elevate its protein contents), however addition of melamine resulted in marked oxidative stress and toxic effect on different body organs, especially the nephrotoxicity and urolithiasis. Therefore, this work is designed to explore the beneficial effect of bee’s honey to alleviate the harmful effect induced by melamine toxicity and to show the histological changes on male albino rats. In this work seven animal groups (five rats for each), group 1; negative control, while groups 2, 4, 6 received melamine-formaldehyde orally at dose 0.9, 90, 9000 ppm, respectively while groups 3, 5, 7 received the same melamine dose beside bee’s honey (dose of 2.5 gm/kg body weight (B. w) for 45 days. Results declared that melamine treated rats showed marked oxidative, biochemical, hematological changes as well as pathological alterations in vital assets especially liver and urinary system. As distension of the urinary bladder, crystals deposition and stone formation were detected with variable degrees in all groups treated only with melamine. Microscopically, various pathological changes in kidneys, liver, lung, heart and intestine were also demonstrated. The severity of these changes varied from mild to severe changes depending upon the dose of melamine. Interestingly, rats treated with melamine plus the bee’s honey showed mild changes in comparison to the only melamine treated rats. These findings assured that, marked antioxidant and and ameliorative effect of bee’s honey successfully reduced the noxious effect of melamine on different body organs. |
