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Dr. Ahlam Farag Elsadek Moharm :: Publications:

Title:
A novel green approach for the treatment of immature Schistosoma mansoni infection in mice with; Arabic gum (Acacia senegal); an antischistosomal agent
Authors: Rabab Selem1 , Samia Rashed1, Mohammad Younis1, Boshra Hussien2, Fatma Mohamed3, Awatif Edrees2, Asmaa EL-kholy1, Gehan Rashed1, Shereen Kishik1*, Ahlam Moharm1, Marwa Nageeb1 and Manal Kardoush
Year: 2018
Keywords: Schistosoma mansoni, immature stages, Arabic gum, antischistosomal agents, mice.
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Ahlam Farag Elsadek Moharm_A novel green approach for the treatment of immature.pdf
Supplementary materials Not Available
Abstract:

Praziquantel (PZQ), the only common schistosocidal drug in use, is not efficacious for treatment of immature schistosomiasis infection. Arabic gum (AG) is a complex polysaccharide that acts as an antioxidant which modulates the inflammatory and/or immunological processes. This study explores for the first time, the antischistosomal properties of AG in mice infected with the immature stage of Schistosoma mansoni (S. mansoni). Mice were divided into four groups: control group (infected nontreated), AG treated group, PZQ treated group, and AG+PZQ treated group. Oral administration of AG in a dose of 1 g/kg body weight, daily for 3 consecutive weeks post-infection (PI) resulted in a statistically significant (P-value 0.002 and 0.008 respectively) lower worm burden in both AG group and AG+PZQ group compared to PZQ and control groups. AG+PZQ group always showed the best results when compared with other groups regarding tissue egg load and oogram pattern. AG, both alone and in combination with PZQ, decreased the granuloma number and diameter; with increasing the cellularity and the number of degenerated Schistosoma eggs inside granulomas. Results obtained by this work elucidated a promising AG bioactivity against S. mansoni immature stages and provided a platform for subsequent experimental studies to illuminate the academia more about this novel and " green" antischistosomal agent.

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