Background
Cardiovasculardisease(CVD)isthemaincauseofdeathinsystemiclupus
erythematosus(SLE)andlupusnephritis(LN)patients.Thisstudyaimedto
evaluatetheprevalenceofmyocardialinjuryamongSLEpatientswithout
nephritisandLNpatients,determinewhetherserum high-sensitivitycardiac
troponinT(HS-cTnT)andcreatinephosphokinase-MB(CKMB)mighthelpto
identifyLN patientsatriskforCVD andidentifyLN asariskfactorfor
myocardialinjury.
Methods:
Thisstudywasconductedon50patients(30LNpatientsand20SLEpatients
withoutnephritis).TheSLEdiseaseactivityindex(SLEDAI)andSystemic
Lupus InternationalCollaborating Clinics Damage Index (SLICC/DI)were
assessed.Laboratoryinvestigations,cardiacenzymes(Hs-TnTandCKMB),
andtransthoracicechocardiographywereperformed.
Results:
OurresultsdemonstratedahigherprevalenceofCVDinLNpatients.28LN
(93.3%)versus10SLE(50%)patientshaddetectablehighsensitivitytroponin
(Hs-TnT)withamean(29.77±18.22ng/L)versus(7.2±6.21ng/L)respectively,
themeanvalueofcreatinephosphokinase-MB(CKMB)washigherinLNthan
SLEpatients(23.9±18.6ug/Lversus14.8±9.4ug/Lrespectively).Multilinear |
