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Dr. AHMED ABDELHAFEZ ABBASS ABDEEN :: Publications: |
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| Title: | The role of Cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin‐11 |
| Authors: | Saki Takahashi, Kanako Muta, Hiroko Sonoda, Ayaka Kato, Ahmed Abdeen, Masahiro Ikeda |
| Year: | 2014 |
| Keywords: | Not Available |
| Journal: | FEBS Open Bio |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | 315-320 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | AHMED ABDELHAFEZ ABBASS ABDEEN_AQP11- FOBS-2014.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Aquaporin‐11 (AQP11) is the latest member of the mammalian water channel protein family to be described. Recent in vivo studies have shown that mutation at Cys227 causes renal failure. However the importance of Cys227 for the molecular function of AQP11 is largely unknown. In this study, we examined the subcellular localization, water permeability, and multimerization of AQP11 with a mutation at Cys227. Interestingly, cells expressing the mutants had significantly higher osmotic water permeability. In contrast, the mutation lowered the cell surface expression and multimerization levels. Our observations suggest that Cys227 is crucial for the proper molecular function of AQP11. |
