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Ass. Lect. Ahmed Fathy Ibrahim Hikal :: Publications: |
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| Title: | Use of a ferret model to test efficacy and immunogenicity of live attenuated Mycobacterium avium subspecies paratuberculosis vaccines |
| Authors: | John P. Bannantine, Tuhina Gupta, Denise K. Zinniel, Ahmed Hikal, Frederick D. Quinn and Raul G. Barletta |
| Year: | 2022 |
| Keywords: | Animal model; Ferrets; Johne’s disease; Mycobacterium; Paratuberculosis. |
| Journal: | Methods Mol Biol |
| Volume: | 2411 |
| Issue: | Not Available |
| Pages: | 95-104. |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | |
| Full paper | Ahmed Fathy Ibrahim Hikal_2022_Book_VaccineDesign.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Native hosts for the bacterial agent that causes Johne's disease are ruminants, which include cattle, sheep and goats among others. These large animals are often too costly to be used in testing experimental vaccines. In this chapter, we provide detailed methods to use an inexpensive and more manageable animal host, the ferret, to test efficacy and immunogenicity of live-attenuated Mycobacterium avium subspecies paratuberculosis (MAP) mutant strains prior to consideration as vaccine candidates. |
