This study evaluated the effects of nitric oxide donor’s treatment on the pregnancy rate and
uterine blood flow in patients with unexplained infertility undergoing clomiphene citrate
stimulation and intrauterine insemination. A total of 120 patients were randomly allocated to a
control group who received 100mg clomiphene citrate daily from day 5 to 9 of cycle plus
placebo vaginal tablets, and a study group received clomiphene citrate plus isosorbide
mononitrate 10mg vaginal tablets. Vaginal ultrasound was done before treatment and every
other day starting from day 12 of cycle to count mature follicles and ovulation was triggered by
IM injection of 10 000 IU hCG when one follicle measured 18mm followed by intrauterine
insemination after 36 h. The endometrial thickness, uterine arteries resistance and pulsation
indices, and endometrial vascular flow and vascular flow indices were measured before
treatment and at day of hCG injection. Results were analyzed after one cycle treatment using
the Mean ± SD, the Student t test and the Fisher Exact test. Significant result was considered at
p values50.05. The study group had significant higher pregnancy rate/cycle, higher
endometrial and lower uterine artery blood flow indices (p50.05). |
