Background: The most serious iatrogenic complication of ovarian stimulation using fertility medications- is considered Ovarian Hyper-stimulation Syndrome (OHSS). The pathogenesis of OHS is attributed to increased vascular permeability causing too much fluid to move from intravascular space into the interstitial space. This can cause potentially serious problems such as dehydration, hypotension and reduced cardiac output. Objective: To investigate the value of using combined diosmin and cabergoline versus using cabergoline alone in avoiding OHSS in high-risk women exposed to assisted reproductive technique. Methods: A prospective cohort study- was carried upon 100 women suspected to be at high-risk for developing OHSS. They were randomly divided into two groups; group I (50 women) received diosmin in addition to cabergoline and group II (50 women) received cabergoline only. After oocyte retrieval, regular assessment clinically and by ultrasonography for all patients- were carried out to detect any evidence of OHSS. Results: The incidence of OHSS was reduced in group I (receiving diosmin combined with cabergoline) than group II (receiving cabergoline alone) 7.3% versus 16.2% respectively, with a statistically significant value(p=0.05). Only, one case of group II developed severe OHSS. No difference in clinical pregnancy rate was recorded between both studied groups. Freeze-all practice was applied to 22 cases of our studied cases. Conclusion: The current study showed that combined use of diosmin and cabergoline- in high-risk women undergoing ART-was competent in avoiding OHSS than using cabergoline alone. Moreover, this combination does not affect pregnancy rate, miscarriage nor multiple pregnancy. |
