I he present study was undertaken to e\'aluate the protectue effect of propranoloi iii comparison \ith \ell established aiitiuleer drugs name!) eimetidine and omepra/olc a^am.M lenoxicam- induced gastric nnicosal injury in rats. The effect of drugs used was judged through a pharmacological and liistological assessment, twenty healthy adults male albino rats were used in this in vivo study. They were equally divided into five groups. The first group received saline only for seven consecutive days through an oio-gastric tube and served as control. The other four groups received tenoxicam in a dail dose of 2mglKg B W for the same period, three of these groups were pretreated \ ith either propranoloi. eimetidine and omeprazole 30 minutes prior to administration ol lenoxicam. All animals were sacrificed 24 hours after the last oral administration and sections from gastric fundus and body were stained for liistological (H. & E. Masson's trichrome and combined PASalcian blue) and histochetnical (succinic deludrogenase and alkaline phosphatase) evaluation. Extensive destruction of gastric mucosa down to the chief cell area was detected in the group of rats which had receixed tenoxicam alone. Variable degrees of protection were observed in the other three group of animals. Isolated rat's fundal strips were used in this in vitro study to confirm the present in vivo results. It was concluded that propranoloi has a protective effect against tenoxicam induced gastric injury in rats and their protective effect is potent and comparable to that of eimetidine and omeprazole. Different mechanisms of propranolol's action, may be implicated, however, prostaglandins are involved |
