Objective: To compare between Intrauterine insemination (lUI) and fallopian tube sperm perfusion (FSP) with controlled ovarian hyperstimulation (COH) as a method of treatment of couples suftering from infertility due to oligospermia.
Design: ProspectIve randomized trial.
Settillf.l: Department of Obstetrics and Gynecology. Benha Faculty of Medicine. Zagazlg University. Department of Dermatology and Venerology, Faculty of Medicine for Girls, AI-Azhar University and authors private clinics.
Patients: We have studied 50 couples during the period from march ]993 till January 1996. All were suffering from primary infertility 1 to 6 years with no apparent cause except male factor in the form of oligospermia with sperm count < 20 millionlml. The of the male partner ranged between 28 and 42 years, while of the female partner ranged between and 38 year. They were divided into two groups, the first group (n =28) have done 40 treatment cycle, while the second group (n 22) have done 28 treatment cycles. There was no significant difference between the 2 groups.
Interventions: All female partners were given the same induction protocol using CC and hMG and follow up by fo]Jiculometry and plasma level. Once, one or more follicle reached size;?; 17 mm, 5000 IU hCG was given 1M. Thirty three hours after administration of hCG, patients were randomly assigned to either lUI with 0.5 ml washed sperm (group I) or FSP with 4 ml husband washed sperm (group 2).
Main o/ltcome measures: Clinical pregnancy was considered by the presence of gestation sac with a fetal pole having pulsating heart at 8 weeks pregnancy by ultrasonography using a vaginal probe.
Results: Although the pregnancy rate is slightly higher in group II treated with FSP (3 pregnancy,
10.71 % per cycle) than group I treated with lUI (3 pregnancy, 7.5 per cycle) there was no significant difference between the two groups.
Conclusion: FSP is a promising technique which needs further study on a large group of patients suffering from various causes of infertility. |
