Sensitive, selective, accurate and precise turbidimetric procedure has been developed for the determination of paracetamol in pure and in dosage forms. The procedure is based on the reduction of siver –gelatin or auric – gelatin complexes in alkaline medium at room temperature after 15 min. the yellow or golden yellow coloured product showed an absorption maximum at 414 and 539 nm with molar absorpitivity of 6.3 x 103 L mol-1 cm-1 and Sandell sensitivity of 0.024 and 0.055 µg cm-2 using Ag+ and Au3+ gelatin complexes, respectively. The determination of 1 -23, and 1 – 35 µg mL-1 of paracetamol using Ag+ and Au3+ gelatin complexes is possible at λmax of each reduction in the precence of additives and excipeints usually present in dosage forms, The RSD is ± 0.95 and 0.83 % on using Ag+ and Au3+ gelatin complexes, respectively. To examine the applicability of the turbidimetric method, the proposed method is succissiffully applied to determine paracetamol in pharmaceutical formulations. |
