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Prof. Alaa El-Sayed Ahmed Ahmed Amin :: Publications:

Spectrophotometric methods for the determination of anti-emetic drugs in bluk and in pharmaceutical preparations.
Authors: A.S. Amin, and G.H. Ragab
Year: 2003
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Local/International: Local
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Four rapid, simple, reproducible and sensitive methods (A-D) for assaying domperidone (I) and metoclopramide (II) in a bulk sample and in dosage forms were investigated. The first and second methods, A and B, are based on the oxidation of I and/or II by Fe3+ in the presence of o-phenanthroline (o-phen) or bipyridyl (bipy). The formation of tris-complex upon reactions with Fe3+-o-phen and/or Fe3+-bipy mixture in an acetate buffer solution of the optimum pH-values was demonstrated. Methods C and D involve the addition of excess Ce4+ and the determination of unreacted oxidant by a decrease of the red color of chromotrope 2R (C2R) at a suitable lambda(max) of 528 nm for method C, or a decrease in the orange pink color of Rhodamine 6G (Rh6G) at a suitable lambda(max) value of 525 nm for method D. A regression analysis of Beer-Lambert plots showed a good correlation in the concentration range of 0.2-5.8 microg ml(-1). The apparent molar absorptivity, Sandell sensitivity, detection and quantification limits were calculated. For a more accurate analysis, the Ringbom optimum concentration ranges are 0.35-5.6 microg ml(-1). The developed methods were successfully applied to the determination of domperidone and metoclopramide in bulk and pharmaceutical preparations without any interference from common excipients.

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