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Prof. Alaa El-Sayed Ahmed Ahmed Amin :: Publications:

Spectrophotometric determination of ampicillin with some nitro compounds.
Authors: Y.M. Issa and A.S. Amin.
Year: 1993
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
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Local/International: Local
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A spectrophotometric procedure for the determination of ampicillin in pure solutions and in its pharmaceutical preparations has been developed. This new method offers advantages of simplicity, rapidity and stability in comparison with the official BP 1980 method. The proposed method is based on the formation of a colour condensation product through the reaction of ampicillin and nitrobenzene derivatives in an alkaline aqueous-acetone medium 40% (v/v). Beer's law is obeyed in the range 0.5–28 μg ml. The colours were produced within 20 min. after heating at 60±5°C and stable for at least 6 h. The method is relatively accurate (recovery 100±2%) and precise (RSD 1.9%) and can be used successfully for the preparation of capsules, syrup and ampoules.

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