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Prof. Alaa El-Sayed Ahmed Ahmed Amin :: Publications:

Utility of certain p-acceptors for the spectrophotometric determination of norfloxacin.
Authors: A.S. Amin, G.O. El-Sayed and Y.M. Issa, Analyst,
Year: 1995
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
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Local/International: Local
Paper Link: Not Available
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Simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of norfloxacin. The methods are based on the reaction of this drug as a π-electron donor with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), 7,7,8,8-tetracyanoquinodimethane (TCNQ), p-chloranil (CL) or chloranilic acid (CLA) as π-acceptors to give highly coloured complex species. The coloured products are measured spectrophotometrically at 460, 843, 550 and 531 nm for DDQ, TCNQ, CL and CLA, respectively. Optimization of the different experimental conditions is described. Beer's law is obeyed in the range 10–400 µg ml–1 and colours were produced in non-aqueous media and were stable for at least 3 h. Applications of the suggested methods to representative pharmaceutical dosage forms are presented and compared with the official method. Interferences from additives and common degradation products were investigated.

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