The biochemical studies have proven that; some domains in the genome have importance more than other regions, because it contains the function parts of those regions. Apical domain in internal ribosome entry site (IRES) of foot and mouth disease virus (FMDV) is one of these domains. There are some nucleotides almost located in conserved motifs of these domains; effect on the structure of these domains which may change its function. Some researches interested in studying the effects which happen in the structure and function of the sequence when some mutation occurred, where these mutations sometimes have a big impact up to producing a new serotype of the viruses as a result of these mutations like SAT1, SAT 2 and SAT3 serotypes. In this paper we produced an observation to the changes of Apical domain in IRES of FMDV on 282 Apical sequences belonging to four different serotypes collected from NCBI portal, and we studied the stable locations and the variable parts in the sequence, and also the paper explained the effectiveness of these mutations in the structure. We introduce this effort as a step to help biologists in knowing the unstable parts in the importance regions which may help in founding the suitable drug or expect the new serotypes of this dangerous virus. |
