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Dr. Alaa Salah Gouda Mohamed Salem :: Publications: |
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| Title: | Novel Assemblies Based on Oligonucleotides Containing Intercalating Nucleic Acid Monomers, Nucleosides, Nucleotides & Nucleic Acids, (2020), 39 (1-3), 82-96. |
| Authors: | Asmaa Abdelrahman, Alaa S. Gouda, Per T. Jørgensen and Jesper Wengel |
| Year: | 2020 |
| Keywords: | DNA; pyrene; naphthalene; pi-interactions; supramolecule |
| Journal: | Nucleosides, Nucleotides & Nucleic Acids |
| Volume: | 39 |
| Issue: | 1-3 |
| Pages: | 82-96 |
| Publisher: | Taylor & Francis Group, LLC |
| Local/International: | International |
| Paper Link: | |
| Full paper | Alaa Salah Gouda Mohamed Salem_Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers.pdf |
| Supplementary materials | Not Available |
| Abstract: |
This is the first report exploring the capability of twisted intercalating nucleic acid (TINA) and naphthalene functionalized non-nucleosidic linkers to stabilize and engage in double-helical structures. Four designs were studied with respect to the formation of duplexes and/or other types of self-assemblies. One of the constructs involving TINA provides a thermostable duplex.The biophysical properties of the individual constructs were investigated by UV thermal melting experiments, circular dichroism, and fluorescence emission spectroscopy. Molecular modeling studies were performed in attempts of explaining the biophysical measurements for the duplex based on the TINA-containing oligonucleotide strands. |
