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Prof. El-Sayed Moustafa Ibrahim Galila :: Publications:

Title:
In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY).
Authors: El-Sayed Moustafa Ibrahim, A.K.M. Shofiqur Rahman, Rie Isoda, Kouji Umeda, Nguyen Van Sa, Yoshikatsu Kodama
Year: 2008
Keywords: C. albicans; IgY; Oral candidiasis
Journal: Vaccine
Volume: 26
Issue: 17
Pages: 2073-2080
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper El-Sayed Moustafa Ibrahim Galila_Vaccine.pdf
Supplementary materials Not Available
Abstract:

We prepared anti-Candida albicans antibody in chicken egg yolk (anti-CA IgY) and investigated its in vitro and in vivo effectiveness. Anti-CA IgY significantly reduced the adherence capacity of C. albicans to FaDu cells (human pharynx carcinoma cells) in a dose-dependent manner. The protective efficacy of anti-CA IgY was investigated in experimentally induced oral candidiasis in immunosuppressed mice. Oral administration of anti-CA IgY significantly reduced the number of C. albicans and the scores of the tongue lesions. Moreover, anti-CA IgY reduced the colonization of C. albicans in mice organs. These results indicate that anti-CA IgY has a protective effect against the oral candidiasis of experimentally infected mice and reduces the dissemination of C. albicans. Putting together, these results indicate that anti-CA IgY is effective against C. albicans. This effect might be due to the blocking of the binding of C. albicans to the host cells. Therefore, anti-CA IgY might be considered as a prophylactic immunotherapy or possibly an adjunctive antifungal therapy.

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