Tetanus is a cut and often highly fatal infectious disease that
affects both human and animals; the disease caused by exotoxin which produced
by C. tetani. In the current study, we try to get hyperimmune IgY in chicken egg
against tetanus toxin and use it as prophylaxis and therapeutic treatment for tetanus. The
obtained IgY titer after inoculation of tetanus toxin in chicken eggs was 1320 limit of
flocculation (Lf-eq) after 72 hr. IgY in adose of 4500 Lf-eq can be protect donkey after
artificial infection by 1 minimum lethal dose (MLD) of C. tetani. While a dose of
30000 Lf-eq IgY intramuscularly two times daily for 2 injections, with 9500
Limit of flocculation Lf-eq IgY intrathecally in subarachnoid space was 100%
curative for a donkey which was challenged with 1 MLD of C. tetani.
Furthermore, IgY was evaluated experimentally in comparison with IgG in
mice. IgY has equally efficacy to IgG in prophylaxis and treatment of tetanus. |
