Introduction: Aflatoxins (AFT) are ubiquitous environmental pollutants that are
extremely dangerous for both human beings as well as animals. A safe, effective,
and considerate strategy is therefore credited with controlling AFT intoxication.
Therefore, our study aimed to evaluate the mitigating properties of Chlorella
vulgaris (ChV) against AFT-induced nephrotoxicity and altered egg quality.
Methods: Quails were randomized into Control group (receiving a normal diet);
ChV group (1 g/kg diet); AFT group (receiving an AFT-containing diet); and the
AFT-ChV group were given both treatments.
Results and discussion: AFT provoked kidney injury, exhibited by increased renal
biochemical parameters and reduced protein levels. Malondialdehyde (MDA)
levels dramatically increased as a consequence of AFT exposure, and
glutathione (GSH) levels, superoxide dismutase (SOD), and glutathione
peroxidase (GPx) activities were also decreased. Substantial up-modulation of
the mRNA expression of the inflammatory cytokines (TNF-α, IL-1β, and IL-6) was
additionally reported. Furthermore, AFT residues were detected in the egg
compromising its quality and nutritional value. Contrarily, ChV supplemented
diet suppressed the AFT-prompted oxidative stress and inflammation, together
with enhancing the nutritional value and quality of eggs and decreasing AFT
residues. These beneficial impacts are proposed to be attributed to its antioxidant
and nutritional ingredients. The molecular docking dynamics confirmed theinflammatory and apoptotic protein targets for ChV. Our findings recommend that
adding ChV supplements to foods might guard against nephrotoxicity brought on
by AFT exposure. |
