The antimicrobial agents, enrofloxacin (EFX), established a growing attention because it's potential
efficacy for the treatment of diseases in human as well as veterinary medicine. The present study was to
recognize the protective effect of different doses of Green tea extract (1%, 1.5% and 3% of GTE) on
enerofloxacin- induced kidneys ultrastructural abnormalities. Treating with EFX caused progresses nephrotoxic
enhancement of glomeruli and acute tubular necrosis on both proximal and distal convoluted tubular cells.
The results of EM studies displayed thickening of glomerular basement membrane GBM as electron-dense
protein deposits along the sub-epithelial facet, mesangium revealed dense depositions. Also, EFX led to loss
of foot processes (pediceles) of the podocytes was visible. Moreover, proximal tubules epithelial cells evoked
necrosis signs with loss of the microvilli, failure of basal membrane enfoldings, large vacuoles and an irregular
basal distribution of the mitochondria in the cytoplasm. The distal convoluted tubule cells showed vesiculated
mitochondria, abnormal nuclei and large dense bodies with loss of organelles. Co- adminsteration of GTE
improved alterations induced by EFX at altitude of the different doses. However, improvement was obvious
after the consumption of higher doses attributed to the antioxidant properties of GTE constituents. |
