utilization of evidence- based nursing practice guidelines during second stage of labor has become a basic women's' health needs, in order to decrease risks for both women and neonates. Aim of the study: to evaluate the implication of applying evidence- based nursing practice guidelines during second stage of labor on maternal and neonatal outcomes. A Quasi-experimental design was used to conduct the current study at delivery room affiliated to obstetric and gynecologic department, Benha University Hospital during the period from January 2015 to April 2015. Subjects: A simple random sample of 279 Primipara women who selected according to the study formula based on the total number of women who admitted to the above setting during 2014.These were randomly allocated into two groups. study group who, had nursing care according to the utilized evidence based guideline ,control group had ordinary nursing care .Tools: Four tools were utilized for data collection, structured interviewing questionnaire sheet, maternal outcomes measurements tool , fatigue assessment scale and neonatal outcomes measurements tool. Results: a highly statistically significant difference between two groups regarding the duration of the second stage, rate of perineal laceration and fatigue and energy subscales scores. Moreover there was a statistically significant difference regarding the incidence of perineal laceration and Apgar score of the neonate during both first and fifth minute. Conclusion; utilization of evidence based nursing practice guideline for management of the second stage of labor decrease the duration of second stage, perineal laceration ,decreases postpartum fatigue, maintain postpartum energy and improve neonatal outcomes. Recommendation; nursing management during the second stage of labor should be provided based on evidence based practice guidelines |