Abstract:
Diabetic nephropathy is one of the major complications of type 1 and type 2 diabetes and it is currently the leading cause of end-stage renal disease. The aim of this study was to investigate the effect of pioglitazone and/or simvastatin on diabetic nephropathy in type 1 diabetic rats and possible mechanism of action especially lipid peroxidation production as malondialdehyde in plasma. Streptozotocin-induced type-1 diabetes mellitus (DM) model was set up in adult male albino rats. Diabetic rats were treated for 8 weeks with pioglitazone (10 mg/kg/day) and/or simvastatin (10mg/kg/day). The serum urea, creatinine, urine albumin, renal histopathology, renal blood flow and lipid perioxidation production as malondialdehyde of the different groups were tested compared to control group. Relative to rats in the normal control group, rats in the diabetic group had significantly disrupted serum urea, creatinine, urinary albumin, renal blood flow, kidney histology and significantly enhanced expression of lipid peroxidation. Rats in the pioglitazone and/or simvastatin treatment group experienced significant amelioration of these effects.
Conclusion: In type 1 diabetic rat model, pioglitazone and/or simvastatin ameliorated many of the physiological, cellular, lipid perioxidation associated with diabetic nephropathy.
|
