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Prof. Amani nasr abdelhady ibrahim :: Publications:

Title:
The Protective Effect of Vitamin D on Cerebral Infarction Fructose Diet
Authors: Eman M.A. Abdelghany, Amany N. Ibrahim
Year: 2015
Keywords: Vitamin D, Insulin Resistance, Cerebrovascular stroke, inflammatory markers, oxidative stress.
Journal: International Archives of Integrated Medicine
Volume: 2
Issue: 11
Pages: 42-50
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Not Available
Supplementary materials Not Available
Abstract:

Abstract Background and aim: the relationship between insulin resistance (IR), hypovitamine D and cerebral infarction and its exact mechanism are not fully understood. However, oxidative stress and pro-inflammatory mediators may be involved. Thus, the aim of the present study was to investigate the effects of vitamin D on cerebral infarction, insulin resistance and inflammatory mediators in rats received high-fructose-diet. Material and methods eight four adult albino rats were divided randomly into 3 groups, normal control group, diabetic group rats received high fructose diet for 2 months without no treatment, diabetic rats received alphacalcidol (10ug//kg/day, orally), which was continued daily throughout the experiment, After 2 months, fasting blood glucose level and insulin, IR was evaluated by the homeostasis model assessment method (HOMA-IR). Some cerebrovascular risk markers as lipid profile (total cholesterol, HDL-C and triglycerides), as well as inflammatory biomarker interleukin-6 and cerebral infarction size were measured. Results rats had high fructose diet showed low 1, 25 (OH)2 D, with a significant (p

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