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Prof. Amani nasr abdelhady ibrahim :: Publications:

Title:
The Protective Effect of Aromatase Inhibitor Anastrozole on Varicocele-Induced Testicular dysfunction in Rats
Authors: Amany N. Ibrahim 1; Magdy I. Attallah 2; Reham Abdelrahman Elnaggar3
Year: 2017
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Amani nasr abdelhady ibrahim_10 Final.docx
Supplementary materials Not Available
Abstract:

Aim: This study aimed to investigate the protective effect of anastrozole on experimental varicocele -induced testicular dysfunction in rats. Material and method: adult male albino rats were divided randomly into three groups; group 1 act as control. In group 2 (varicocele rats) varicocele was induced by partial ligation of the left renal vein. Group 3 (anastrozole-treated group) varicocele rats received anastrozole (400mg/l) in the drinking water for a period of 9 weeks immediately after ligation of the left renal vein. Serum FSH, LH, testosterone and intratesticular testosterone were measured. Seminal parameters (progressive motility, sperm cell concentration, epididymal sperm abnormal forms) were estimated. Testicular tissue specimens were histopathologically examined by hematoxylin & eosin staining. Results :after 9 weeks of operation, the varicocele induced significant decreased of bilateral intratesticular testosterone levels and marked impairment of seminal parameters and histopathological changes in the rat tests compared with control group (p

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