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Dr. Amany Ibrahim Mustafa :: Publications: |
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| Title: | Cross talk between oxidative stress and inflammation in alopecia areata |
| Authors: | Amany Ibrahim Mustafa 1, Rana Atef Khashaba 2, Eman Fawzy 3, Shimaa Mohamad AbdElRahman Baghdady 4, Shymaa Mostafa Rezk 1 |
| Year: | 2021 |
| Keywords: | Not Available |
| Journal: | journalof cosmetic dermatology |
| Volume: | 20 |
| Issue: | 7 |
| Pages: | Not Available |
| Publisher: | Wiley |
| Local/International: | International |
| Paper Link: | |
| Full paper | Amany Ibrahim Mustafa_J of Cosmetic Dermatology - 2020 - Mustafa - Cross talk between oxidative stress and inflammation in alopecia areata (4).pdf |
| Supplementary materials | Amany Ibrahim Mustafa_J of Cosmetic Dermatology - 2020 - Mustafa - Cross talk between oxidative stress and inflammation in alopecia areata (4).pdf |
| Abstract: |
Abstract Background: Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development. Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators, C-reactive protein (CRP). Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP. Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031, |
