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Dr. Amal Mohammed Mohammed Saeed :: Publications:

Toll Like Receptor-4 Gene Polymorphism and Susceptibility to Pulmonary Tuberculosis
Authors: Nehad A. Fouad¹, Amal M. Saeed¹, Ahmed W Mahedy 2 & 3
Year: 2019
Keywords: Not Available
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Local/International: Local
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Full paper Amal Mohammed Mohammed Saeed_8.pdf
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Tuberculosis (TB) affects human life globally for a long time. The difference in clinical outcome of infection suggests that host genetic makeup is responsible for such variability. Toll like receptors (TLRs) are pattern recognition receptors and have a significant role in mycobacterial recognition by the innate immune system. TLR-4 is the key receptor in initiation of innate immunity against M. tuberculosis. This study investigated whether variants in TLR-4 896A/G (Asp299Gly) and TLR-4 1196C/T (Thr399Ile) genes are related with susceptibility or resistance to pulmonary tuberculosis (PTB) in Saudi population. Genotyping of TLR-4 896A/G, TLR-4 1196C/T gene was performed by polymerase chain reaction followed by restriction fragment length polymorphism (PCR –RFLP) in 60 PTB patients and 60 control subjects. The A allele at (896A/G) was more frequent in the control group while G allele was more common in PTB patients. The frequency of T allele of (1196C/T) polymorphism was significantly increased in PTB patients as compared to the control group (P

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