Introduction: Hypothyroidism is the most common form of thyroid disorder throughout the world.
Subclinical hypothyroidism has been associated with adverse metabolic, cardiovascular, neuromuscular,
and cognitive effects and has been shown to have a detrimental impact on quality of life. Though there are
many literatures regarding the effect of hypothyroidism on pulmonary function but few studies revealing
the influence of subclinical hypothyroidism on pulmonary functions are found.
Aim of the Study: To evaluate the left ventricular diastolic dysfunction in individuals with subclinical
hypothyroidism and evaluate their relation to (FEV1%, FVC%, FEF 25-75%).
Results: The study included 50 cases (group 1) and 45 controls (group 2). There was Lower TSH,
FT3, reduced E wave velocity, E/A ratio with increased A wave velocity, prolonged DT and IVRT, lower
(FEV1, FVC, FEF25-75) % in group 1. TSH showed a negative correlation with E wave velocity, E/A
ratio and the three pulmonary function indices with a strong positive correlation with IVRT. IVRT has a
moderate negative correlation with FVC%. Correlations between other echocardiograpic parameters of LV
dysfunction and pulmonary function indices were weak.
Conclusion: Subclinical hypothyroidism patients are more prone to left ventricular diastolic dysfunction
so they should be screened by doppler echocardiography for early diagnosis and management. Although
the pulmonary function alterations in subclinical hypothyroidism are mild, they should not be ignored.
Further studies are needed to decide whether these changes are enough to establish thyorxine replacement
therapy.
© 2019 Published by Innovative Publication. This is an open access article under the CC BY-NC-ND
license (https://creativecommons.org/licenses/by/4.0/) |
