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Dr. Amira Ibrahim Mansour Ahmed :: Publications: |
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| Title: | Decrease of serum biomarker of type II Collagen
degradation (Coll2-1) by intra-articular injection of
an autologous plasma-rich-platelet in patients with
unilateral primary knee osteoarthritis |
| Authors: | Rasha Mohamed Fawzy1 , Nashwa Ismail Hashaad1 , Amira Ibrahim Mansour2 |
| Year: | 2017 |
| Keywords: | Platelet-rich plasma, growth factors, serum coll2-1, knee osteoarthritis, Western Ontario, McMaster Universities Arthritis Index Score |
| Journal: | European Journal of Rheumatology |
| Volume: | 4 |
| Issue: | Not Available |
| Pages: | 93-97 |
| Publisher: | Medical Research and Education Society |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Amira Ibrahim Mansour Ahmed_Coll2-1.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Objective: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional status of the osteoarthritic knee joint. Material and Methods: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group Ι): including patients with KL grade < 3 and (Group ΙΙ): including patients with KL grade ≥3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was prepared and injected immediately into the affected knee. Serum Coll2-1 (S.Coll2-1) concentration was measured by enzyme-linked immunosorbent assay (ELISA) kit pre and 3 months after PRP injection. Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p |
