Abstract: Background: Acute myocardial infarction (AMI) pathophysiology is mediated by systemic,
intraplaque myocardial inflammatory processes that occur mainly due to coronary artery
thrombosis in an atherosclerotic plaque area. The G-protein-coupled chemokine receptor (Ccr6) is
displayed on the surface of many types of leukocytes, that have been found in atherosclerotic
plaques. It is a novel mediator of inflammation and immune response.
Objectives: To determine CCR6 lymphocyte expression in AMI patients and its association with
disease severity using the Gensini scoring system.
Methods: 25 AMI patients and 25 controls underwent flow cytometry to determine the percentage
of circulating CCR6+ lymphocytes. To forecast AMI and determine how CCR6 expression relates
to it, multivariate logistic regression analysis was used.
Results and Discussion: There was a higher percentage of CCR6+ lymphocyte expression in AMI
patients than in controls. In addition, CCR6 showed a significant positive correlation with the Gensini
score (GS) in the AMI group then with the degree of coronary artery disease (CAD).
Conclusion: The chemokine receptor CCR6 is an independent biomarker for AMI and mayplay a
role as a mediator of T lymphocyte recruitment, which is associated with coronary lesion destabilization. |
