BACKGROUND: Interleukin-17F (IL-17F), one of the cytokines, is crucial in the pathophysiology of juvenile idiopathic arthritis (JIA).
Therefore, we aimed to determine the relation between IL17F 7488A/G and IL17F 7383A/G single-nucleotide polymorphisms and
JIA susceptibility and to explain their impact on the disease activity.
METHODS: Genomic DNA of 70 patients with JIA and 70 age and sex-matched controls were extracted and typed for IL17F 7488A/
G and IL17F 7383A/G single-nucleotide polymorphisms, using polymerase chain reaction with sequence-specific primers method,
and compared between patients and controls.
RESULTS: When compared to AA participants, children with the AG genotype of the IL17F 7488A/G and IL17F 7383A/G
polymorphisms showed a substantially greater risk of JIA. Furthermore, children with the G allele were 2.8 folds more likely to have
JIA than the A allele for IL17F 7488A/G polymorphism and 3.72 folds for IL17F 7383A/G polymorphism. Children with AG genotype
of IL17F 7383A/G polymorphism were far more likely to have high activity JIA.
CONCLUSIONS: The G allele of both IL17F 7488A/G and IL17F7383 A/G polymorphisms is associated with increased JIA
susceptibility, and JIA at High Disease Activity was more likely to develop in AG subjects of the IL17F 7383 A/G polymorphism.
Pediatric Research; https://doi.org/10.1038/s41390-022-02288-1 |
