Objective: To test if the change in glycated hemoglobin (HbA1c) over a follow-up interval of approximately one year would be associated with concomitant changes in Low Density Lipoprotein Levels cholesterol (LDL-c) in young adult with type 1 diabetes (T1D). Also to determine T1DM patients who would be eligible for lipid-lowering medications based on American Diabetes Association (ADA) guidelines.
Methods: our retrospective comparative study included 81 patients with T1D who attended and follow in Diabetes out patient clinics of Kuwait primary health care centers during the period of 2013-2014; for them, recorded data for age, sex, duration of diabetes, Body Mass Index (BMI), HbA1c and LDL-c at the beginning and at the end of one year duration were included in this study.
Results: We are reporting data on a population of n=81 subjects with T1DM with mean age (19.38 ±6.332 years).Female and male distribution was 48.1%% and 51.9 respectively, Means of HbA1c and LDL.c at initial visit were (10.8 ± 2 % and 2.9 ± 0.9 mmol/l) and (9.8 ± 2% and 2.6 ± 0.8 mmol/l) after one year of follow up. Our result showed that there was a significant positive correlation between HbA1c and LDL. c at beginning (r= 0.312; P= 0.005) and (r= 0.259; P= 0.019) after one year of follow up; which means that change in HbA1c over time was significantly associated with change in LDL-c.
Conclusions: As LDL.c considered a major risk factor for coronary heart disease in patients with diabetes, so our study revealed that improved glucose control was associated with a more favorable LDL.c levels and this reflect that in the case of adolescents with type 1 diabetes, good control of diabetes seems to be of paramount importance.
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