Background: Several studies have revealed that BNP levels may reflect diastolic dysfunction.But, few studies demonstrated the role of BNP in early detection of diastolic dysfunction in diabetic patients. Hence there is a need, for recognizing those with asymptomatic left ventricular diastolic dysfunction, and at a risk of developing clinical HF. Purpose: the study is aimed at evaluating the role of BNP in the early identification of diastolic dysfunction. Methods: 60 patients with type 2 DM were included in the study of those attending medical and diabetic polyclinic in the state of Kuwait through a period of 6 months in 2012. Results: The mean age of the patients was 53.87 ± 7.98 years. They were 23 (38.3%) males and 37 (61.7%) females. A total of 20 patients (33.3%) out of 60 patients were diagnosed with LVDD. The patients with LVDD had a higher BNP levels (P=0. 000**) in comparison to the patient without LVDD. Receiver operating characteristic curve (ROC) was generated for identifying the sensitivity and specificity of the BNP and the area under the curve was 1.000 at a cutoff value >92 pg/ml was 100% specificity and 100% sensitive for detecting the presence or absence of LVDD by echocardiography with 100% PPV and 100% NPV. Conclusion: The BNP assay could be used as a marker of early LV diastolic dysfunction in diabetic patients for early prevention and management of overt heart failure. |
