Globally trichinellosis (Trichinella species) is a risky parasitic zoonosis Anthelminthic such as oral albendazole® and mebendazole® commonly used to treatment are poorly water soluble with unfavo- rable bioavailability. This study evaluated the therapeutic efficacy of lactoferrin loaded on silver nanoparticles on Trichinella spiralis infection in experimental infected mice by parasi-tological and histopathological parameters. Mice were classified into 8 groups each of 5 mice. G1: Non infected non treated (normal), G2: Infected non treated (infected control), G3: In-fected and albendazole, treated, G4: Infected and lactoferrin treated, G5: Infected and silver na-noparticles treated, G6: Infected and lactoferrin loaded on silver nanoparticles treated, G7: Infe-cted and albendazole & lactoferrin, & G8: Infected and albendazole combined with lactoferrin loaded on silver nanoparticles treated.
The results showed a significant decrease in all treated groups, markedly in T. spiralis larval muscles treated with combination of albendazole and lactoferrin loaded on silver nanoparticles (92.39%), with muscles histopathological changes. |
