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Dr. Assistant prof. Ashraf Mohamed Abd Ellatief Nasif :: Publications:

Title:
Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish(Carassius auratus auratus)
Authors: Mohamed Aboubakr , Abdelazem Mohamed Abdelazem and Ashraf Mohamed Abdellatif
Year: 2014
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Ashraf Mohamed Abd Ellatief Nasif _Final JFTP.pdf
Supplementary materials Not Available
Abstract:

The pharmacokinetic of norfloxacin (10 mg kg-1) following single intravenous (IV) and oral administration (PO) in healthy goldfish were investigated. Also, repeated (PO) administration of norfloxacin in healthy and experimentally Aeromonas hydrophilia infected goldfish was studied. Following IV administration, norfloxacin obeyed a two compartments open model, distribution half-life (t1/2(α)) equal to 0.12 h, volume of distribution (Vdss) was 1.01 L kg-1, elimination halflife (t1/2(β)) was 4.30 h and total body clearance (CLtot) was 0.17 L kg-1h-1. Following PO administration, norfloxacin was rapidly and efficiently absorbed through gastrointestinal tract as the absorption half-life (t1/2(ab)) was 0.84 h. Maximum serum concentration (Cmax) 4.10 μg ml-1, was achieved its maximum time (tmax) at about 2 h post administration and the elimination half-life (t1/2(el)) was 3.91 h. Oral bioavailability was 57.63% indicating moderate absorption of norfloxacin from oral site. Serum concentrations of norfloxacin following repeated PO administration of 10 mg kg-1 BW once daily for 5 consecutive days, were significantly lower in experimentally Aeromonas hydrophilia infected goldfish than in healthy ones. Based on these pharmacokinetics parameters determined, a dosage of 10 mg kg-1 BW given orally every 24 h in goldfish can maintain effective plasma concentrations with Aeromonas hydrophilia infection with (minimum inhibitory concentration) MIC90 ≤ 0.25 μg ml-1. Therefore, norfloxacin may be an effective therapy for goldfish diseases.

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