The pharmacokinetics (after single intravenous, and oral
administration) and tissue residues after repeated oral (daily for five
days) administration of apramycin were investigated in normal and
experimentally Escherichia coli infected chickens. Apramycin was
administered at a dose level of 25 mg/kg b. wt. (for oral
administration) and at 10 mg/kg b. wt. for intravenous injection. Fourty
six clinically normal Hubbard chicken of four weeks of age weighting
about 1500 to 2000 grams were used in the current study. The
maximum plasma concentrations of apramycin were achieved 0.705
µg/ml at 0.5 hour after oral administration and 35.09 µg/ml at 0.083
hours after intravenous injection. The systemic bioavailability was 1.31% after oral
administration indicating poor absorption of apramycin. After intravenous injection, the
pharmacokinetics of apramycin was best described by a three-compartment open model with
at t1/2α of 0.113 hour, t l/2β of 0.999 hour, t0.5(ɤ) of 4.56 hour, Vdss of 1460.19 ml/kg. The plasma
protein binding of apramycin was 7.13 ± 0.444 %. oral administration of 25 mg apramycin
per kilogram body weight three times daily for five consecutive days in normal and
Escherichia coli infected chickens revealed a lower significant serum apramycin
concentration in Escherichia coli infected chickens compared with normal chickens. The
highest tissue concentrations of apramycin were present in the kidneys and liver. |
