Toxoplasmosis is a cosmopolitan parasitic
disease that impacts enormous
population sector. In this work we
investigated the antitoxoplamic therapeutic
effect of one synthetic drug;
nitazoxanide (NTZ) and another agent
of plant origin; Zingiber officinale
(ginger) as adjuvant to the traditional
antotoxoplamic drugs (pyrimethamine
& sulphadiazine) on experimental murine
toxoplasmosis (RH virulent
strain). Animals were classified into 7
groups; GI: Non-infected, non- treated
(normal control), GII: Infected non
-treated mice (infected control), GIII:
Infected & treated by a combination
of pyrimethamine & sulphadiazine
(drug control), Group IV: Infected &
treated by Zingiber officinale GV:
Infected & treated by nitazoxanide,
GVI: Infected & treated by combination
of Zingiber officinale and pyrimethamine
& sulphadiazine, Group
VII: Infected & treated by combination
of Zingiber officinale & nitazoxanide.
For assessment of the therapeutic
effect of various drug regimens on
acute toxoplasmosis, survival rate and
intraperitoneal fluid tachyzoite count
were calculated. In the present study,
Group VI achieved the best results
among all studied groups so as to the
survival rate increased to 70% and
the tachyzoites count reduction rate
was up to 72.9% as compared with
the infected control mice. Inversely,
group IV results were the lowest all
over other groups with 20% survival
and 33.3% tachyzoite reduction rates
respectively. In between, the other
groups lied in the grey zone and their
corresponding measurements were as
following: Group III, Group V and
Group VII achieved 60%, 70%; 50,
58% and 40%, 55.5% for survival
and tachyzoite reduction rates respectively.
These results denote that nitazoxanide
could be an acceptable,
standardized, characterized, already
FDA approved and commercially
available substitute to traditional antitoxiplasmic
synthetic drug. Also Zingiber
officinale would be a safe and
beneficial adjuvant treatment that
potentiates the antitoxoplasmic action
THERAPEUTIC EFFECT OF NITAZOXANIDE AND ZINGIBER OFFICINALE
IN TREATMENT OF ACUTE TOXOPLASMOSIS GONDII USING MURINE
EXPERIMENTAL MODEL
By
Mohammed HussienSaleh1; Amina Ibrahim Abdel–Maaboud1,
Rabab Fawzy Mohammed Selem1, Hassan Ali Elfadaly2,
AsmaaAbd El Monem El- Kholy1, Nagat Ahmed Soliman 1
1Medical Parasitology Department, Faculty of Medicine, Benha University, Egypt
Medicine, Benha University, Egypt.
2Zoontic Diseases Department, National Research Center, (NRC), Egypt of the traditional treatment of toxoplasmosis.
More studies are needed to
address the dose response relationship
of both NTZ and Zingiber officinale
before using them for treatment of
acute toxoplasmosis. |
