The efficacy of Zingiberofficinale
extract (ZOE)against toxocariasis
was investigated in experimental
mice and results were compared to
those obtained using albendazole
and combination of albendazole and
Zingiberofficinale extract (Albz)
Sixty malealbino mice, 10 weeksold,
were classified into 6 experimental
groups of 10 mice each:
Group I: None infected, non-treated
(normal control) and received 0.1
ml of sterile distilled water. Group
II: Infected mice with T. canis eggs
(infected control). Group III: Infected
mice by treated eggs with
ZOE (T. canis eggs were incubated
24h with 500 mg/ml of ZOE before
mice inoculation. Group IV: Infected
mice by T. canis eggs and treated
by albendazole (drug control).
Group V: Infected mice by T. canis
eggs and treated by ZOE. Group
VI: Infected mice by T. canis eggs
and treated by combination of albendazole
and ZOE. The present
study showed that, Zingiberofficinale
extract (ZOE) had a significant
inhibitory effect on the larval recovery
rates in the brain and eye
compared to the infected and drug
controls. Combination of albendazole
and Zingiberofficinale extract
(Albz) reduced the larval counts by
higher percentages attaining the
best results. The most obvious reduction
in larval counts was observed
in GVI to be 94.50% and
96.34% respectively. It was observed
that the larvae in all treated
groups showed sluggish movement
Zingiberofficinale improved the induced
pathological changes by Toxocara
in the studied organs that regressed
to near normal picture after
its combination with Albz. And
Zingiberofficinale seemed to be effective
as albendazole against T. canis
infection. However, a greater effect
was obtained by their combination. |
