O2-free radicals play a major role in the pathogenesis of many
inflammatory conditions and malignancy. Aiso, sialic acid (Total & Lipid-
Bound) were recorded to be disturbed in inflammation and malignancy. So,
the aim of this work is to study the relationship between O2-free
radicals, lipid-bound sialic acid (LSA), total sialic acid (TSA) and
carcino-embryonic anitgen (CEA) in patients with chronic bronchitis &
bronchogenic carcinoma. Also, to evaluate LSA & TSA as Tumor markers
in patients with bronchogenic carcinoma and assessed the individual and
combined values of LSA, TSA, & CEA determination in these patients,
To clarify this isssue, two groups of patients were studied. The first
group included 20 patients with chronic bronchitis. Their age ranged from
(44-5S) years. The second group included another 20 patients with
bronchogenic carcinoma. Their age ranged from (45-62). These groups of
patients were compared with 10 healthy, age and sex matched as controls.
The results of this study showed that; patients with chronic
bronchitis and bronchogenic carcinoma have a significant increase of serum
lipid peroxides (LP), LSA and TSA (P<0.001) while serum CEA is
significantly increased only in patients with bronchogenic carcinoma
compared with the control group (PO.001). Also, there was a significant
positive correlation between serum LP and LSA (P<0.01), TSA (P<0.001)
in patients with chronic bronchitis while, there was non-significant positive
correlation with serum CEA. Also, there was a significant positive
correlation between serum LP and LSA (P<0.001), TSA (PO.001) and
CEA (P<0.05) in pat ients with bronchogenic carcinoma. Serum LSA
is more sensitive biochemical marker (80%) than TSA (75%) and
serum CEA (60%) whi le serum CEA is more specific marker
(73.3%) in
Bull. Egypt Soc. Physiol. Sci., 18(2) 1998 224
Awad M. El-Abd et al.,
diagnosis of patients with bronchogenic carcinoma than serum LSA
(46.7%) and TSA (33.3%).
We could conclude that, the increase of O2- free radicals may be the trigger
for the increase of serum level of cell surface related sialoglycoprotein,
sialoglycolipids, and tumor antigen (CEA). Neither one of the three
biomarkers success to be absolutely diagnostic nor pathognomonic for
bronchogenic carcinoma but, the combined measurement of LSA and CEA
in serum may be helpful for better detection potential of bronchogenic
carcinoma than either of the two markers alone. So, we recommend to
interpretate the results carefully in these group of patients to assure that
inflammation or other benign conditions are not causing changes in the test
values. |
