The effect of acute myocardial infarction (AMI) on some proinflammatory
cytokines, as well as their relationship to serum lipids
needs to be clarified. The current work was carried on 45 male subjects.
Their ages ranged from 43-56 years. They were 25 patients with AMI
compared with 20 healthy subjects matched for the same age and sex as
controls. For all subjects, serum interleukin-1 (IL-1), interleukin-6 (IL-6)
and tumor necrosis factor –alpha (TNF-α) and lipid profile were assayed
24 hours post infarction and 6 weeks later on.
The results of this work showed that serum IL-1, IL-6 and TNF-α
were significantly increased 24 hours post infarction and 6 weeks later
compared with the control group (p<0.05). However, serum IL-1, IL-6
and TNF-α were significantly decreased 6 weeks later after the onset of
infarction compared with the same parameters 24 hours post infarction
(p1 < 0.05).
Also, lipid profile showed a significant change in serum low
density lipoprotein-cholesterol(LDL-c), very low density lipoproteincholesterol(
VLDL-c) and triglycerides 24 hours post infarction and 6
weeks post infarction while serum total cholesterol and high density
lipoprotein-cholesterol(HDL-c) showed a significant change 6 weeks post
infarction(p<0.05) ..However, serum total cholesterol and HDL-c had
non-significant change 24 hours post infarction when they compared with
the control group.
Comparative study of serum lipid profile 6 weeks post infarction
versus 24 hours post infarction, the data revealed that; a significant
increase in serum total cholesterol and serum LDL-c while a significant
2
decrease was found in serum HDL-c, VLDL-c and triglycerides
(p1<0.05)
Correlation study at 24 hours post infarction, revealed that serum
IL-1, IL-6 and TNF-α had non-significant correlation with serum lipid
profile .On the other hand serum IL-6 had a significant negative
correlation with serum LDL (r= - 0.550) and serum TNF-α had a
significant positive correlation with serum VLDL (r=0.582) and
triglycerides (r=0.498) 6 weeks later after the onset of AMI
So, this study revealed that ,serum IL-1, IL-6 and TNF-α were
prominent markers for inflammation following AMI either at the onset or
shortly thereafter . They had been implicated in abnormal lipid
metabolism. Serum cholesterol levels were no longer valid 24 hours after
AMI while serum triglycerides is preferred for diagnosis of
hyperlipidaemia . However, it remains to be determined whether these
markers of inflammation actually have a causal relation with the
cardiovascular disease, or simply reflect the underlying disease process.
Such determination becomes important with the potential use of these
markers in targeting preventive therapies. |
