The current study was aimed to find out the percentage of low
serum B12 and folate and their interactions with serum total homocysteine
level in Egyptian women experiencing unexplained recurrent miscarriage.
A total of 50 women were studied for determination of serum B12, folate
and total homocysteine, of them 20 women were primary aborters and 15
women were secondary aborters and 15 healthy women who served as
controls. Their age ranged from 19-40 years with the mean value 30.5
years . The results of this work showed significant differences between the
percentage of those with low serum B12 and folate in primary, secondary
and all aborters compared with the control group (p<0.05). Also, the
percentage of those with high serum homocysteine showed a significant
difference in primary and all aborters but not in secondary aborters when
compared with the control group. On the other hand, the mean values of
serum B12, folate and homocysteine showed significant differences in all
women with recurrent miscarriage compared with the control group
(p<0.05). Statistical correlation showed significant negative correlation
between serum folate and total homocysteine in primary aborters ( r= -
0.449 p<0.05).We could conclude that ; there were an interaction between
deficiencies of B12 and folate with hyperhomocysteinemia which may
contribute to the etiology of unexplained recurrent early pregnancy loss.
Identification of those women with hyperhomocysteinemia may be of help
in therapeutic normalization and might permit a normal birth. |
