Hyperlipidemia, thrombophilia and hyperhomocysteinemia were
all known metabolic risk factors for coronary heart disease. The
association between the extra-gastric effects of chronic helicobacter
pylori (h.pylori) infection and these risk factors in dyspeptic patients
needs to be clarified. Forty subjects were studied for determination of
serum total cholesterol, triglycerides, very low density lipoproteincholesterol
(VLDL-c), low density lipoprotein-cholesterol (LDL-c), high
density lipoprotein-cholesterol (HDL-c), plasma clotting factors VII, X,
XII activities, fibrinogen concentration, antithrombin III (ATIII) activity
as well as plasma total homocysteine. They were 26 males and 14
females. Their age ranged from 31 to 41, with a mean value of 35.8±2.6
years. They were categorized according to the concentration of h.pylori
antibodies (IgG) into 15 patients who were seronegative and another 15
patients who were seropositive. These patients were compared with 10
healthy subjects, age and sex matched who served as controls. The results
of the present work showed that; serum lipid profile had no significant
differences in seronegative and seropositive patients for h.pylori infection
compared with the control group (p>0.05). Moreover, plasma clotting
factors VII, X, XII had no significant changes while plasma fibrinogen
concentration and total homocysteine were significantly higher in
seropositive compared with both seronegative patients and the control
group (p<0.05). Additionally, seropositivity correlated significantly with
plasma fibrinogen concentration (r=0.76 ; p<0.05).
It could be concluded that, alteration of plasma fibrinogen and total
homocysteine might be considered metabolic risk factors for coronary
heart disease in dyspeptic patients due to chronic h.pylori infection.
However, estimation of these biomarkers are recommended to avoid the
future risk of ischemic heart disease. |
